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KMID : 0861020000150020009
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Korea Journal of Herbology
2000 Volume.15 No. 2 p.9 ~ p.15
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Effect of Arisaematis Rhizoma on the Proliferation of Transplanted - L1210 cells in Mice
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Abstract
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We have previously observed that the proliferation of L1210 cells was inhibited by the administration of Arisaematis Rhizoma water extract (AE). In this present study, the mechanism of the inhibitory action on the proliferation of L1210 cells was examined. AE decreased the proliferation of L1210 cells and enhanced DNA fragmentation of L1210 cells in vivo system. DNA fragmentation of L1210 cells was enhanced by co-culture of peritoneal macrophages obtained from AE-administered mice in vitro. AE increased nitric oxide production from peritoneal macrophages of L1210-transplanted mice. In addition, AE enhanced the population of CD4^+CD8 cells. These results suggest that the inhibitory action of AE on the proliferation of L1210 cells is partly caused by an induction of apoptosis via a production of nitric oxide in macrophages activated by Th cells.
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